Le CRCINA, avec le soutien du consortium MiBioGate, a le plaisir de vous inviter au Séminaire du professeur Guy Gorochov
Le sujet de son intervention sera :
Relations publiques et privées entre microbiote et anticorps
Immune/bacterial interface in health and disease
Man has developed spectacular ways to protect himself from pathogens, while benefitting from unique and essential features of symbionts. We postulate that a perturbation of this balance is predisposing to, or is aggravating diseases such as systemic autoimmunity and cancer. The role played by IgA at the immune-microbiota interface was studied in controls and patients with selective IgA deficiency. Each individual targets a diverse, but nevertheless private microbiota repertoire. Partially overlapping anti-carbohydrate binding patterns, observed both at the isotypic and clonal level, could explain these apparently opposing features of IgA, being at the same time cross-reactive and selective in its interactions with the microbiota. Although absent from the gut, serum anti-microbiota IgG (mostly IgG2) are present in healthy individuals, and converge with secretory IgA to target the same bacterial cells. The latter observation emphasizes the close link between local and systemic anti-microbiota immunity.